Conference on Progress in Alzheimer and Parkinson's Disease
Seville, Spain, May 8-12, 2003
This book consists of a
collection of 27 papers written by selected authors, who had presented
their research at the 6th. International Conference on Progress in
Alzheimer’s and Parkinson’s Diseases (AD/PD 2003) that took place on May
8-12, 2003, in Seville Spain.
It serves as a companion
piece to the Official Proceedings (OP) of the conference, which will be
published later this year by the Martin Dunitz and Parthenon Publishing
Since there was a limit to
the number of chapters that could be included in the OP, we restricted
the contributions to chapters based on oral, invited presentations at
the meeting. Monduzzi Editore has provided an avenue for the publication
of selected additional chapters in the context of this book, thus
expanding the scope of available information from the AD/PD 2003
In the interest of saving
time and allowing rapid publication, we agreed with Monduzzi Editore’s
request that, as editors, we would only correct major mistakes or errors
in scientific logic and fact. We would not concern ourselves with differences in font type, style,
or referencing in these chapters.
A more thorough and extensive editorial
process will be employed with the OP manuscript.
We hope that this book will provide the
reader with a modest overview of the scope and breadth of topics that
were covered in the AD/PD 2003 conference. We also thank the authors for
preparing their chapters at relatively short notice.
I. Hanin, Ph.D.
A. Fisher, Ph.D.
R. Cacabelos, M.D., Ph.D.
Abnormal Cerebral MRIs In Mild Cognitive Impairment
J. Meyer1, A. El-Gengaihy, J. Thornby, M.
Chowdhury, E. Maus, R. Fahmy and M. Quach
Cerebral Blood Flow Deficit on 123I-IMP SPECT in Advanced Parkinson’s
H. Shibayama, K. Funakoshi, S. Sato, H.
Nishino and T. Maki
Correlates of Cognitive Impairment in Lewy Body Disorders
C.S. Lee, B.L. Beattie, H. Feldman, V.
Sossi, M.J. Adam, I.R. Mackenzie, A.J. Stoessl and T.J. Ruth.
Cognitive Impairment Risk and Protective Factors Prevalence in 2043
Individuals Over 65. Correlation with Memory Self-Evaluation and SPMSQ
R.L. Arizaga, R.F. Allegri, C.A. Mangone,
J.A. Ollari, O. Genovese and C. Abel
Cerebrovascular Risk Factors and Brain Hemodynamics in Dementia
V. Pichel, I. Etcheverría, L. Amado, Y. Kubota and R.
Antibodies to AChE586-599 Distinguish Alzheimer’s Patients from Controls
J. Voskuil, M. Cottingham and D.J Vaux
Lipopolysaccharides Induce Inflammation-Mediated Neurodegeneration in
the Substantia Nigra and Cerebral Cortex (A Case Report)
Effects of Leg Muscle Training on Parkinson’s Disease Patients
T. Kondo, R. Kodama, J. Kohmoto, I.
Nakanishi, S. Morita,
Y. Hiwatani, H. Miwa and S. Maeshima
Partial Purification and Characterization of
from Post Mortem Human Brain
M.R. Farmery, L.O. Tjernberg, S.E.
Pursglove, A. Bergman, B. Winblad and J. Näslund
Calcium Dyshomeostasis in the Course of Disease in Individual Patients
with Alzheimer´s Dementia
V. Platilová and R. Jirák
Flow Cytometry Analysis of CD28-/CD8+ Suppressor Cell Precursor and
CD45RO+/CD4+ Memory T Lymphocytes in the Peripheral Blood of Alzheimer’s
Disease (AD) Patients
V.R.M. Lombardi, L. Amado, L.
Fernández-Novoa, I. Etcheverría, S. Seoane and R. Cacabelos
Nitric Oxide in Alzheimer Disease
L. Corzo, R. Zas, L. Fernández-Novoa and R.
Galantamine for Alzheimer´s Disease: A Novel Antiapoptotic Mechanism
Linked to Overexpression of Bcl-2 and
E. Arias, E. Ales, M.F. Cano-Abad, M.
Villarroya, A.G. Garcia and M.G. Lopez
Glucagon-like Peptides: New Therapeutic Strategy for Neurodegeneration
T.A. Perry, K. Sambamurti, D.K. Lahiri, M.P.
Mattson, J.M. Egan and N.H. Greig
Mannan as a Molecular Adjuvant for Ab-Immunotherapy
D.H. Cribbs, A. Lees, A. Ghochikyan, V.
Vasilevko, I. Petrushina, D. Babikyan, N. Movsesyan, M. Tran, A.
DeVolger and M.G. Agadjanyan
Combination Therapy in Alzheimer Disease: A Pharmacogenomic Study
Y. Kubota, V. Pichel, L. Fernández-Novoa
and R. Cacabelos
APOE Genotype-Related Brain Atrophy in the Spanish Population
I. Etcheverría, V. Pichel, L. Amado, L. Fernández-Novoa, V.
Lombardi and R. Cacabelos
Park 8 – New Locus for an Autosomal Dominant Japanese Family
Hasegawa Kazuko, Funayama Manabu, Kowa
Hisayuki, Tsuji Shoji and Obata Fumiya
Identification and Analysis of PACRG, a Novel Gene Linked to Parkin Via
a Bi-directional Promoter
P.J. Lockhart, A.B. West, C. O’Farrell, M.
de Lucia, D.W. Dickson and M.J. Farrer
Molecular Genetic Analysis of DRD2 and MAOB Loci in Patients with
Parkinson’s Disease Treated with Dopamine Agonists and/or Specific MAO-B
M. Watanabe, S. Nissato, N. Ohkoshi, T.
Yoshizawa, K. Yoshizawa, A. Hayashi and S. Shoji
Association Study Between Polymorphisms in the Promoter Region of the
Alpha-synuclein Gene and Alzheimer’s Disease
H. Ujike, N. Uchida, A. Sakai, H.
Kobayashi, J. Hasegawa, M. Yamamoto, Y. Fujisawa, Kanzaki, I. Kohira, M.
Nakashima, Y. Takehisa, I. Sora and S. Kuroda.
ACE Gene in Alzheimer’s Disease
L. Fernandez-Novoa, V.R.M. Lombardi, S. Seoane, I.
Etcheverria, L. Corzo and R. Cacabelos
BACE Protein Expression Is Stimulated by IFN-g
H.S. Hong and I. Mook-Jung
Polyclonal Sera from Wildtype Mice Recognized Predominantly EFRH Epitope
G. Gevorkian, I. Petrushina, A. Ghochikyan,
K.G. Manoutcharian, G. Acero,
D.H. Cribbs and M.G. Agadjanyan
Neprilysin Mediated Prevention of Amyloid Plaque Formation
M.H. Mohajeri, R. Poirier, H. Li, M.A.
Wollmer and R.M. Nitsch
Effects of ZSET845 and ZSET1446 on Acetylcholine Release in the Cortex
and Learning Impairments in the Rat
Y. Yamaguchi, M. Takano, K. Saitoh, T.
Matsuno and S. Kawashima
Cognitive-enhancing Properties of Galantamine Analogues in Rats and Mice
A. Gower, C. Williams, M. Smith and K.