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INDEX

This volume contains several papers presented at the 12th International Conference on Second Messengers and Phosphoproteins held in Montreal in August 3-7, 2004 (SMP-2004). This conference series was initiated in 1971, the same year that Dr. Earl W. Sutherland, Jr. won the Nobel Prize for the discovery of the first second messenger cyclic AMP. Since then, this conference has been held every 3 years in different parts of the world. The field of second messengers and phosphoprotein signaling has grown enormously during the last 30 years as a result it is now recognized that second messengers and phosphorylation/dephosphorylation evoked signaling pathways regulate a large array of cellular events. The cellular functions controlled by these pathways include cell survival, growth, differentiation, migration and metabolism. The scientific program of the SMP-2004 was designed to reflect the multifaceted role of second messengers and phsophoprotein signaling system on various biological processes. The various topics covered in this conference included adhesion signaling, calcium and phosphodiesterase, cell cycle, chemical biology and signaling, cyclic nucleotide and AMP signaling, G-protein coupled receptors, protein kinases and phosphatases, and therapeutic modulation of signaling system. The conference was opened by a keynote lecture by Dr. Tony Pawson from University of Toronto followed by several plenary as well as symposia talks presented by world experts in the field of cell signaling. A large number of posters were also presented at this conference. This volume, although represents a small fraction of the total presentations made at this conference, gives a glimpse of various topics that were covered at SMP-2004. We would like to thank many companies and organizations for their generous support for the SMP-2004 as well as the members of the Organizing Committee for their contributions. We would also like to thank the authors for submitting their work for this book and the staff at the Medimond Monduzzi Editore International Proceedings Division for putting this volume together.

Madhu B. Anand-Srivastava, Ph.D.
Michel Tremblay, Ph.D.
Ashok K. Srivastava, Ph.D.

Montreal, December 17, 2004
 

INDEX

Molecular Functions of Tsg101
I. Amit, K.-U. Wagner and Y. Yarden

Stimulation of Protein Phosphatase 5 Activity In Vivo
P.T.W. Cohen and T. Zeke

b-arrestin-recruited Phosphodiesterase-4D Determines Switching of b2-adrenoceptor Signalling from Gs to Gi
M.D. Houslay and G.S. Baillie

WNK1
B.-H. Lee, B-e. Xu, X. Min, L. Lenertz, C.J. Heise, E.J. Goldsmith and M.H. Cobb

Inducing the Selective Death of Cancer Cells In Vitro and In Vivo
A. Levitzki

Impact of EGF on Endosomal Rafts: A Proteomic Approach
A. Parmar, A. Balbis, G. Baquiran and B.I. Posner

Alterations in Adenylyl Cyclase Activity are Dependent upon the Type of Heart Failure
R. Sethi, H.K. Saini and N.S. Dhalla

Role of SLP-76 in Vascular Development and TCR Signal Transduction
M. Silverman, F. Abtahian, M. Kahn and G. Koretzky

Structure, Function and Regulation of AMPK
B. van Denderen, T. Iseli, J. Adams, G. Steinberg, Z-P. Chen, B.J. Michell, S. Murthy, I. G Jennings, G. McConell, L. Witters, D. Stapleton and B.E. Kemp

Dok-R Mediated Signaling. Migration and Much More
P. Van Slyke, S. Chen, C. Sturk, Z. Master and D.J. Dumont

Spatio-temporal Regulation of Rho-family GTPases During Cell Division as Visualized by FRET-based Probes
H. Yoshizaki and M. Matsuda

* * *

Phosphatidic Acid and the Arabidopsis PDK1-MPK6 Connection
R.G. Anthony, J. Costa, R. Henriques and L. Bögre

Nitric Oxide Decreases the Expression of Gi-Protein and Adenylyl Cyclase Signaling in Vascular Smooth Muscle Cell
M. Bassil and M.B. Anand-Srivastava

The Protein Kinase Reource
O. Buzko, H. Niedner, N. Haste, A. Taylor, M. Gribskov and S. Taylor

Reactive Oxygen Species Impaire the Signaling of Sperm Functions
S.-J. Chang, H.-C. Weng, C.-C. Hsu, C.-W. Tang and C.-J. Chang

Transgenic Rats Overexpressing Heat Shock Protein 70 Exhibit Differential Cardiac Expression of the Protein Kinase C Isoforms
S.D. Coaxum and R. Mestril

Perinatal Pulmonary Arterial Calcium Desensitization: CPI-17 Mediated Regulation of Myosin Phosphatase
S. Dakshinamurti

Evidence for the Presence of SAM68-related Proteins of Higher Molecular Weight in the HL-60 Human Cell Line
C. Gilbert, S. Castonguay, F. Barabé, R. Delage, P.A. Tessier, M.J. Tremblay and P.H. Naccache

Discovery and Characterization of the First Peptide FML1 Antagonists
E. Gutknecht, S. Poirey, W. Fischli, O. Nayler and X. Leroy

The cAMP Receptors Epac and PKA Synergize To Induce PC12 Cell Neuritogenesis and To Protect Against Apoptosis
H. Hagland, F. Selheim, T.J. Keen, Kaja Skjćrven, C. Krakstad, A-E. Christensen, L. Herfindal, F. Schwede, H-G. Genieser and S.O. Dřskeland

Detection of a Variety of Protein Kinases Using Multi-PK Antibodies
I. Kameshita, N. Sueyoshi and K. Okazaki

Lysophosphatidic Acid Induces Phosporylation of Heat Shock Protein 27
P. Komalavilas, L. DaCosta and C.M. Brophy

Suppression by Dibutyl Phthalate on the Ca2+ Signaling in Bovine Chromaffin Cells
Pei-Shan Liu and Fu-Wei Tseng

Cell-specific Effects of Diphenyleneiodonium (DPI) on Insulin–induced Signaling Events
M.Z. Mehdi and A.K. Srivastava

Cytosolic Levels of Calpastatin Are Regulated by Limited Proteolysis
E. Melloni, R. De Tullio, M. Averna, R. Stifanese,
F. Salamino and S. Pontremoli

Na+/K+ Pump As Endothelial Cell Death Receptor Triggered By Ouabain
S.N. Orlov, N. Thorin-Trescases, D. Pchejetski, O. Akimova,
S. Taurin, J. Tremblay, E. Thorin and P. Hamet

Molecular Characterization of the Interaction Between Calreticulin and Protein Kinase C
M. Robles-Flores, M.C. Castańeda-Patlán, H. González-Aguilar and G. Flores

cAMP Signal Pathways in Membrane Microdomains Regulate Src Kinase Signaling
A. Ruppelt, E.M. Aandahl and K. Taskén

Involvement of Rolipram-Sensitive Phosphodiesterase in Amylase Release in Rabbit Parotid Acinar Cells
N. Sairennji, K. Shibutani, S. Furuyama and H. Sugiya

Visual Real-time Analysis of Extracellular Matrix Proteins’ Effects on Breast Cancer Cell Invasion Into Reconstituted Collagen Gels
K. Sakai and Y. Fujita-Yamaguchi

Pretreatment of Naive Cells with IFNb Leads to a Significant Transcriptional Activation of the Lipopolysaccharide (LPS) Inducible Interferon Stimulated Gene-54K (ISG54)
S. Sakamoto and A.C. Larner

aCaMKII Cellular Redistribution in Ca2+ Overload
K. Török, P.A.A. Grant, S.L. Best and R. Alessio

Permanent Neurotensin Cell Sensitization and Chronic Map Kinase Activation Is Obtained Under Saturating and Permanent Agonist Exposure and Cell Division
M. Toy-Miou-Leong, F. Souazé, A. Beaudet, W. Rostčne and P. Forgez

Phosphoinositide 3-kinase (PI3K) Regulates Excitation-Contraction Coupling in Cardiomyocytes
C.J. Vlahos, S.A. McDowell, W.F. Matter, T.B. Estridge and E. McCall

Suppression of Receptor-mediated Apoptosis by CK2
G. Wang, A.T. Davis and K. Ahmed

Regulation of Elk-1 Phosphorylation and c-fos mRNA Expression in Striatal Neurons by Metabotropic Glutamate Receptors
J.Q. Wang and L. Mao

Functional Dissection of Human Protease µ-calpain Using RNAi
M. Wu, Z. Yu, J. Fan, A.W. Caron, M. Whiteway and S.-H. Shen

Regucalcin and Cell Signaling: Overexpression of Regucalcin Suppresses Cell Death and Apoptosis
Masayoshi Yamaguchi

Toluene Diisocyanate Inhibits the Calcium Signaling in Human Neuroblastoma Cells
Yin-Mei Chiung, Yi-Yun Kao,
Han-Ting Chen and Pei-Shan Liu

Ethanol-Responsive Domains in Adenylyl Cyclase
M. Yoshimura and S. Pearson